- Title
- Life-threatening hypokalaemia associated with ibuprofen-induced renal tubular acidosis
- Creator
- Page , Colin B.; Wilson, Paul A.; Foy, Aidan; Downes, Michael A.; Whyte, Ian M.; Isbister, Geoffrey K.
- Relation
- Medical Journal of Australia Vol. 194, Issue 11, p. 613-614
- Relation
- https://www.mja.com.au/journal/2011/194/11
- Publisher
- Australasian Medical Publishing Company
- Resource Type
- journal article
- Date
- 2011
- Description
- We read with interest the article by Ng and colleagues on life-threatening hypokalaemia associated with ibuprofen-induced renal tubular acidosis,1 and wish to present our own experience of four patients presenting to our hospital over a year. The patients all presented with biochemical signs of renal tubular acidosis with severe hypokalaemia and a normal anion gap metabolic acidosis from long-standing misuse of ibuprofen taken in combination with codeine from over-the-counter (OTC) medications. Patients 1 and 2 presented acutely with deliberate misuse that included an ibuprofen–codeine combination product. Both patients subsequently admitted to long-standing misuse of ibuprofen and codeine taken in combination. Patients 3 and 4 presented with constitutional symptoms and generalised weakness with a history of taking large amounts of an ibuprofen–codeine combination product. Both these patients required intensive care unit admission for central venous access and potassium replacement.
- Subject
- hypokalaemia; ibuprofen; renal tubular acidosis
- Identifier
- http://hdl.handle.net/1959.13/1048086
- Identifier
- uon:14870
- Identifier
- ISSN:0025-729X
- Language
- eng
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